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GDF9 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GDF9 Antibody (N-term) AP2069a
    The anti-GDF9 N-term Pab (Cat. #AP2069a) is used in Western blot to detect GDF9 in HL60 cell lysate.
  • IHC-P - GDF9 Antibody (N-term) AP2069a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • WB - GDF9 Antibody (N-term) AP2069a
    Western blot analysis of GDF9 (arrow) using rabbit polyclonal GDF9 Antibody (M45) (Cat. #AP2069a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GDF9 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60383
Other Accession NP_005251
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51444 Da
Antigen Region 30-59 aa
Additional Information
Gene ID 2661
Other Names Growth/differentiation factor 9, GDF-9, GDF9
Target/Specificity This GDF9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human GDF9.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGDF9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF9
Function Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
Cellular Location Secreted.
Tissue Location Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level)
Research Areas
Citations ( 0 )


GDF9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues.Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. GDF9 is expressed in oocytes and is thought to be required for ovarian folliculogenesis.


Liao, W.X., et al., J. Biol. Chem. 278(6):3713-3719 (2003).
Vitt, U.A., et al., Biol. Reprod. 67(2):473-480 (2002).
Aaltonen, J., et al., J. Clin. Endocrinol. Metab. 84(8):2744-2750 (1999).
Dong, J., et al., Nature 383(6600):531-535 (1996).
McGrath, S.A., et al., Mol. Endocrinol. 9(1):131-136 (1995).

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$ 295.00
$ 99.00
Cat# AP2069a
(40 western blots)
Availability: In Stock
Bulk Size
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