|Application ||WB, E|
|Other Accession||Q9R1J8, Q3V1T4|
|Calculated MW||83394 Da|
|Other Names||Prolyl 3-hydroxylase 1, Growth suppressor 1, Leucine- and proline-enriched proteoglycan 1, Leprecan-1, LEPRE1, GROS1, P3H1|
|Target/Specificity||This LEPRE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 499-533 amino acids from the Central region of human LEPRE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LEPRE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.|
|Cellular Location||Isoform 1: Endoplasmic reticulum.|
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Provided below are standard protocols that you may find useful for product applications.
Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.
Kaul S.C.,et al.Oncogene 19:3576-3583(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Cabral W.A.,et al.Nat. Genet. 39:359-365(2007).
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