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HUMAN-CTNND1_isform 2ABC(Y174) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - HUMAN-CTNND1_isform 2ABC(Y174) Antibody AP20722b
    All lanes : Anti-HUMAN-CTNND1_isform 2ABC(Y174) Antibody at 1:16000 dilution Lane 1: A431 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: MCF-7 whole cell lysate Lane 4: MDA-MB-231 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 108 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - HUMAN-CTNND1_isform 2ABC(Y174) Antibody AP20722b
    All lanes : Anti-HUMAN-CTNND1_isform 2ABC(Y174) Antibody at 1:2000 dilution Lane 1: A431 whole cell lysate Lane 2: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 108 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O60716
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 108170 Da
Additional Information
Gene ID 1500
Other Names Catenin delta-1, Cadherin-associated Src substrate, CAS, p120 catenin, p120(ctn), p120(cas), CTNND1, KIAA0384
Target/Specificity This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 160-200 amino acids from human.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHUMAN-CTNND1_isform 2ABC(Y174) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTNND1
Synonyms KIAA0384
Function Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Cellular Location Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm Isoforms 4A and 1AB are excluded from the nucleus. Isoform 2A: Nucleus.
Tissue Location Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.
Research Areas
Citations (0)

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Background

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

References

Keirsebilck A.,et al.Genomics 50:129-146(1998).
Nagase T.,et al.DNA Res. 4:141-150(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Kim L.,et al.Mol. Cell. Biol. 15:4553-4561(1995).

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$ 295.00
$ 99.00
Cat# AP20722b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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