|Application ||WB, E|
|Other Accession||P84087, P84086, P84088|
|Calculated MW||15394 Da|
|Other Names||Complexin-2, Complexin II, CPX II, Synaphin-1, CPLX2|
|Target/Specificity||This CPLX2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 51-83 amino acids from the Central region of human CPLX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPLX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons.|
|Tissue Location||Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity).
McMahon H.T.,et al.Cell 83:111-119(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Raevskaya N.M.,et al.Gene 359:127-137(2005).
Harrison P.J.,et al.Lancet 352:1669-1673(1998).
Eastwood S.L.,et al.Brain Res. Bull. 55:569-578(2001).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.