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CPLX2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - CPLX2 Antibody (Center) AP20736c
    Western blot analysis of lysate from mouse brain tissue, using CPLX2 Antibody (Center)(Cat. #AP20736c). AP20736c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6PUV4
Other Accession P84087, P84086, P84088
Reactivity Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 15394 Da
Additional Information
Gene ID 10814
Other Names Complexin-2, Complexin II, CPX II, Synaphin-1, CPLX2
Target/Specificity This CPLX2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 51-83 amino acids from the Central region of human CPLX2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCPLX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPLX2
Function Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).
Cellular Location Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons.
Tissue Location Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
Research Areas
Citations (0)

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Background

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity).

References

McMahon H.T.,et al.Cell 83:111-119(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Raevskaya N.M.,et al.Gene 359:127-137(2005).
Harrison P.J.,et al.Lancet 352:1669-1673(1998).
Eastwood S.L.,et al.Brain Res. Bull. 55:569-578(2001).

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$ 295.00
$ 99.00
Cat# AP20736c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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