|Application ||WB, E|
|Other Accession||Q8CHT0, Q7SY23, A7YWE4|
|Predicted||Bovine, Zebrafish, Mouse|
|Calculated MW||61719 Da|
|Other Names||Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase, ALDH4A1, ALDH4, P5CDH|
|Target/Specificity||This ALDH4A1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 522-556 amino acids from the C-terminal region of human ALDH4A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALDH4A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Hu C.-A.,et al.J. Biol. Chem. 271:9795-9800(1996).
Stagos D.,et al.Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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