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SYCP3 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SYCP3 Antibody (N-term) AP20774a
    Western blot analysis of lysate from human testis tissue lysate, using SYCP3 Antibody (N-term)(Cat. #AP20774a). AP20774a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8IZU3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27729 Da
Additional Information
Gene ID 50511
Other Names Synaptonemal complex protein 3, SCP-3, SYCP3, SCP3
Target/Specificity This SYCP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 13-46amino acids from the N-terminal region of human SYCP3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYCP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYCP3
Synonyms SCP3
Function Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q60547}. Chromosome {ECO:0000250|UniProtKB:Q60547}. Chromosome, centromere {ECO:0000250|UniProtKB:Q60547}. Note=It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres {ECO:0000250|UniProtKB:Q60547}
Tissue Location Testis-specific.
Research Areas
Citations (0)

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Background

Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).

References

Martinez-Garay I.,et al.Genomics 80:259-267(2002).
Adamah D.J.B.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Miyamoto T.,et al.Lancet 362:1714-1719(2003).

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$ 295.00
$ 99.00
Cat# AP20774a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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