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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Csk Antibody (N-term)   

Mouse Csk Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • IHC-P - Mouse Csk Antibody (N-term) AP20789a
    Immunohistochemical analysis of paraffin-embedded M.spleen section using Mouse Csk Antibody (N-term)(Cat#AP20789a). AP20789a was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • WB - Mouse Csk Antibody (N-term) AP20789a
    Western blot analysis of lysate from mouse liver tissue lysate, using Mouse Csk Antibody (N-term)(Cat. #AP20789a). AP20789a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P41241
Other Accession P32577, P41240, Q0VBZ0
Reactivity Mouse
Predicted Bovine, Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50716 Da
Additional Information
Gene ID 12988
Other Names Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase MPK-2, p50CSK, Csk
Target/Specificity This Mouse Csk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 67-101amino acids from the N-terminal region of human Mouse Csk.
Dilution IHC-P~~1:25
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Csk Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Csk
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
Cellular Location Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts
Tissue Location Ubiquitous, but most abundant in thymus and spleen, as well as in neonatal brain
Research Areas
Citations (0)

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Background

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).

References

Klages S.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:2597-2601(1994).
Farber C.R.,et al.Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Gilardi-Hebenstreit P.,et al.Oncogene 7:2499-2506(1992).
Lubec G.,et al.Submitted (JAN-2009) to UniProtKB.

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$ 295.00
$ 99.00
Cat# AP20789a
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Quantity:
(40 western blots)
Availability: In Stock
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