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KCNJ16 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KCNJ16 Antibody (Center) AP20842c
    Western blot analysis of lysate from rat brain tissue lysate, using KCNJ16 Antibody (Center)(Cat. #AP20842c). AP20842c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NPI9
Other Accession P52191, Q9Z307
Reactivity Rat
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 47949 Da
Additional Information
Gene ID 3773
Other Names Inward rectifier potassium channel 16, Inward rectifier K(+) channel Kir51, Potassium channel, inwardly rectifying subfamily J member 16, KCNJ16
Target/Specificity This KCNJ16 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 286-319 amino acids from the Central region of human KCNJ16.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNJ16 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNJ16
Function Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201).
Cellular Location Membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10.
Tissue Location Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.
Research Areas
Citations (0)

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Background

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.

References

Liu Y.,et al.Cytogenet. Cell Genet. 90:60-63(2000).
Derst C.,et al.FEBS Lett. 491:305-311(2001).

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$ 295.00
$ 99.00
Cat# AP20842c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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