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(Mouse) Wdr5 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - (Mouse) Wdr5 Antibody AP20952a
    Western blot analysis of lysates from human liver tissue and mouse NIH/3T3 cell line(from left to right), using (Mouse) Wdr5 Antibody(Cat. #AP20952a). AP20952a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P61965
Other Accession Q498M4, P61964
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 36588 Da
Additional Information
Gene ID 140858
Other Names WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WD repeat-containing protein BIG-3, Wdr5, Big, Big3
Target/Specificity This Mouse Wdr5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the region of mouse Wdr5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(Mouse) Wdr5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Wdr5
Synonyms Big, Big3
Function Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in liver (at protein level). Detected in brain, testis and kidney
Research Areas
Citations (0)

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Background

Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).

References

Gori F.,et al.J. Biol. Chem. 276:46515-46522(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Jiang H.,et al.Cell 144:513-525(2011).
Yang Y.J.,et al.Cell 151:1097-1112(2012).
Diao Y.,et al.Cell Stem Cell 11:231-241(2012).

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$ 295.00
$ 99.00
Cat# AP20952a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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