|Application ||WB, E|
|Other Accession||Q8K3P4, O43347|
|Calculated MW||39119 Da|
|Other Names||RNA-binding protein Musashi homolog 1, Musashi-1, Msi1, Msi1h|
|Target/Specificity||This mouse Msi1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 81-113 amino acids from the Central region of mouse Msi1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||(Mouse) Msi1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Detected in olfactory bulb, brain stem, small intestine, and at low levels in brain cortex, hippocampus and ovary. Detected in neural progenitor cells, including neural stem cells.|
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Provided below are standard protocols that you may find useful for product applications.
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Sakakibara S.,et al.Dev. Biol. 176:230-242(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Imai T.,et al.Mol. Cell. Biol. 21:3888-3900(2001).
Sakakibara S.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:15194-15199(2002).
Nagata T.,et al.J. Mol. Biol. 287:315-330(1999).
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