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NOVA1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • IHC-P - NOVA1 Antibody (Center) AP20983a
    Immunohistochemical analysis of paraffin-embedded H. astroglioma section using NOVA1 Antibody (Center)(Cat#AP20983a). AP20983a was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
  • WB - NOVA1 Antibody (Center) AP20983a
    All lanes : Anti-NOVA1 Antibody (Center)(AP20983a) at 1:1000 dilution Lane 1: A431 whole cell lysates Lane 2: Hela whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 49 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - NOVA1 Antibody (Center) AP20983a
    Western blot analysis of lysates from A431, Hela cell line (from left to right), using NOVA1 Antibody (Center)(Cat. #AP20983a). AP20983a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P51513
Other Accession Q9JKN6
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional Information
Other Names RNA-binding protein Nova-1, Neuro-oncological ventral antigen 1, Onconeural ventral antigen 1, Paraneoplastic Ri antigen, Ventral neuron-specific protein 1, NOVA1
Target/Specificity This NOVA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 139-173 amino acids from the Central region of human NOVA1.
Dilution IHC-P~~1:25
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNOVA1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOVA1
Function May regulate RNA splicing or metabolism in a specific subset of developing neurons.
Cellular Location Nucleus.
Tissue Location Brain. EMBL; U04840; AAA16022.1; -; mRNA EMBL; AK289639; BAF82328.1; -; mRNA EMBL; AK291022; BAF83711.1; -; mRNA EMBL; AL079343; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL132716; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471078; EAW65990.1; -; Genomic_DNA EMBL; CH471078; EAW65991.1; -; Genomic_DNA EMBL; CH471078; EAW65992.1; -; Genomic_DNA EMBL; CH471078; EAW65993.1; -; Genomic_DNA EMBL; CH471078; EAW65995.1; -; Genomic_DNA EMBL; BC075038; AAH75038.1; -; mRNA EMBL; BC075039; AAH75039.1; -; mRNA EMBL; Z70771; CAA94810.1; -; mRNA CCDS; CCDS32060.1; -. [P51513-5] CCDS; CCDS32061.1; -. [P51513-4] CCDS; CCDS9635.1; -. [P51513-2] PIR; I38489; I38489 RefSeq; NP_002506.2; NM_002515.2. [P51513-4] RefSeq; NP_006480.2; NM_006489.2. [P51513-5] RefSeq; NP_006482.1; NM_006491.2. [P51513-2] UniGene; Hs.31588; - PDB; 1DT4; X-ray; 2.60 A; A=424-495 PDB; 2ANN; X-ray; 2.30 A; A=49-249 PDB; 2ANR; X-ray; 1.94 A; A=49-249 PDBsum; 1DT4; - PDBsum; 2ANN; - PDBsum; 2ANR; - ProteinModelPortal; P51513; - SMR; P51513; - BioGrid; 110919; 10 IntAct; P51513; 8 MINT; P51513; - STRING; 9606.ENSP00000438875; - iPTMnet; P51513; - PhosphoSitePlus; P51513; - BioMuta; NOVA1; - DMDM; 1709303; - EPD; P51513; - MaxQB; P51513; - PaxDb; P51513; - PeptideAtlas; P51513; - PRIDE; P51513; - ProteomicsDB; 56315; - ProteomicsDB; 56316; -. [P51513-2] ProteomicsDB; 56317; -. [P51513-3] ProteomicsDB; 56318; -. [P51513-4] TopDownProteomics; P51513-2; -. [P51513-2] Ensembl; ENST00000344429; ENSP00000342387; ENSG00000139910. [P51513-2] Ensembl; ENST00000465357; ENSP00000447391; ENSG00000139910. [P51513-5] Ensembl; ENST00000539517; ENSP00000438875; ENSG00000139910. [P51513-4] GeneID; 4857; - KEGG; hsa:4857; - UCSC; uc001wpy.4; human. [P51513-1] CTD; 4857; - DisGeNET; 4857; - EuPathDB; HostDB:ENSG00000139910.19; - GeneCards; NOVA1; - H-InvDB; HIX0037755; - HGNC; HGNC:7886; NOVA1 HPA; HPA004155; - MIM; 602157; gene neXtProt; NX_P51513; - OpenTargets; ENSG00000139910; - PharmGKB; PA31688; - eggNOG; KOG2191; Eukaryota eggNOG; ENOG410XRZD; LUCA GeneTree; ENSGT00760000119144; - HOGENOM; HOG000007833; - HOVERGEN; HBG082048; - InParanoid; P51513; - KO; K14944; - OMA; VVDFIMD; - OrthoDB; EOG091G185U; - PhylomeDB; P51513; - TreeFam; TF316981; - ChiTaRS; NOVA1; human EvolutionaryTrace; P51513; - GeneWiki; NOVA1; - GenomeRNAi; 4857; - PRO; PR:P51513; - Proteomes; UP000005640; Chromosome 14 Bgee; ENSG00000139910; - CleanEx; HS_NOVA1; - ExpressionAtlas; P51513; baseline and differential Genevisible; P51513; HS GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA GO; GO:0005730; C:nucleolus; IDA:HPA GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:0003729; F:mRNA binding; IEA:Ensembl GO; GO:0003723; F:RNA binding; HDA:UniProtKB GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc GO; GO:0007626; P:locomotory behavior; TAS:ProtInc GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl GO; GO:0051252; P:regulation of RNA metabolic process; IEA:Ensembl GO; GO:0006396; P:RNA processing; TAS:ProtInc GO; GO:0008380; P:RNA splicing; TAS:ProtInc Gene3D; 3.30.1370.10; -; 3 InterPro; IPR004087; KH_dom InterPro; IPR004088; KH_dom_type_1 InterPro; IPR036612; KH_dom_type_1_sf InterPro; IPR033086; NOVA1 PANTHER; PTHR10288:SF223; PTHR10288:SF223; 1 Pfam; PF00013; KH_1; 3 SMART; SM00322; KH; 3 SUPFAM; SSF54791; SSF54791; 3 PROSITE; PS50084; KH_TYPE_1; 3 1: Evidence at protein level; 3D-structure; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding CHAIN 1 510 RNA-binding protein Nova-1 /FTId=PRO_0000050116 DOMAIN 49 119 KH 1. {ECO:0000255|PROSITE- ProRule:PRU00117} DOMAIN 174 240 KH 2. {ECO:0000255|PROSITE- ProRule:PRU00117} DOMAIN 424 491 KH 3. {ECO:0000255|PROSITE- ProRule:PRU00117} MOTIF 27 43 Bipartite nuclear localization signal COMPBIAS 276 412 Ala-rich MOD_RES 157 157 Phosphoserine {ECO:0000250|UniProtKB:Q9JKN6} VAR_SEQ 88 90 Missing (in isoform 2, isoform 4 and isoform 5). /FTId=VSP_002841 VAR_SEQ 153 176 Missing (in isoform 3 and isoform 5) /FTId=VSP_002842 VAR_SEQ 177 184 VKIIVPNS -> KHNISWIS (in isoform 2) /FTId=VSP_002843 VAR_SEQ 185 510 Missing (in isoform 2) /FTId=VSP_002844 STRAND 50 57 {ECO:0000244|PDB:2ANR} HELIX 58 65 {ECO:0000244|PDB:2ANR} HELIX 67 69 {ECO:0000244|PDB:2ANR} HELIX 70 79 {ECO:0000244|PDB:2ANR} STRAND 82 85 {ECO:0000244|PDB:2ANR} STRAND 98 107 {ECO:0000244|PDB:2ANR} HELIX 109 123 {ECO:0000244|PDB:2ANR} HELIX 148 151 {ECO:0000244|PDB:2ANR} STRAND 177 182 {ECO:0000244|PDB:2ANR} HELIX 183 190 {ECO:0000244|PDB:2ANR} HELIX 192 194 {ECO:0000244|PDB:2ANR} HELIX 195 203 {ECO:0000244|PDB:2ANR} STRAND 207 210 {ECO:0000244|PDB:2ANR} STRAND 221 229 {ECO:0000244|PDB:2ANR} HELIX 230 245 {ECO:0000244|PDB:2ANR} STRAND 425 432 {ECO:0000244|PDB:1DT4} TURN 433 436 {ECO:0000244|PDB:1DT4} HELIX 437 440 {ECO:0000244|PDB:1DT4} HELIX 442 444 {ECO:0000244|PDB:1DT4} HELIX 445 454 {ECO:0000244|PDB:1DT4} STRAND 457 460 {ECO:0000244|PDB:1DT4} STRAND 472 479 {ECO:0000244|PDB:1DT4} HELIX 481 494 {ECO:0000244|PDB:1DT4} SEQUENCE 510 AA; 52056 MW; 7B9BA8B67CAB6984 CRC64; MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKLSK SKDFYPGTTE RVCLIQGTVE ALNAVHGFIA EKIREMPQNV AKTEPVSILQ PQTTVNPDRI KQTLPSSPTT TKSSPSDPMT TSRANQVKII VPNSTAGLII GKGGATVKAV MEQSGAWVQL SQKPDGINLQ ERVVTVSGEP EQNRKAVELI IQKIQEDPQS GSCLNISYAN VTGPVANSNP TGSPYANTAE VLPTAAAAAG LLGHANLAGV AAFPAVLSGF TGNDLVAITS ALNTLASYGY NLNTLGLGLS QAAATGALAA AAASANPAAA AANLLATYAS EASASGSTAG GTAGTFALGS LAAATAATNG YFGAASPLAA SAILGTEKST DGSKDVVEIA VPENLVGAIL GKGGKTLVEY QELTGARIQI SKKGEFVPGT RNRKVTITGT PAATQAAQYL ITQRITYEQG VRAANPQKVG
Research Areas
Citations (0)

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Background

May regulate RNA splicing or metabolism in a specific subset of developing neurons.

References

Buckanovich R.J.,et al.Neuron 11:657-672(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Venter J.C.,et al.Science 291:1304-1351(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Dmitrenko V.V.,et al.Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.

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$ 295.00
$ 99.00
Cat# AP20983a
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(40 western blots)
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