|Application ||WB, E|
|Calculated MW||27579 Da|
|Other Names||C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, SR-PSOX, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, CXCL16, SCYB16, SRPSOX|
|Target/Specificity||This CXCL16 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 150-183 amino acids from the Central region of human CXCL16.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CXCL16 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a soluble form|
|Tissue Location||Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus Weak expression in heart and liver and no expression in brain and bone marrow|
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Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Matloubian M.,et al.Nat. Immunol. 1:298-304(2000).
Wilbanks A.,et al.J. Immunol. 166:5145-5154(2001).
Shimaoka T.,et al.J. Biol. Chem. 275:40663-40666(2000).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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