|Application ||WB, E|
|Calculated MW||134164 Da|
|Other Names||Protein jagged-1, Jagged1, CD339, Jag1|
|Target/Specificity||This (Mouse) Jag1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1103-1137 amino acids from the C-terminal region of mouse Jag1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||(Mouse) Jag1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in many tissues, with highest expression in brain, heart, muscle and thymus|
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Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis.
Shimizu K.,et al.J. Biol. Chem. 274:32961-32969(1999).
Loomes K.M.,et al.Hum. Mol. Genet. 8:2443-2449(1999).
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