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Mouse Isl1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Isl1 Antibody (C-term) AP20999c
    Western blot analysis of lysate from rat brain tissue lysate, using Isl1 Antibody (C-term)(Cat. #AP20999c). AP20999c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P61372
Other Accession P61374, P61371, P53405, P50211
Reactivity Rat
Predicted Chicken, Zebrafish, Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39036 Da
Additional Information
Gene ID 16392
Other Names Insulin gene enhancer protein ISL-1, Islet-1, Isl1
Target/Specificity This Mouse Isl1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 302-336 amino acids from the C-terminal region of mouse Isl1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Isl1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Isl1
Function DNA-binding transcriptional activator (PubMed:14664703, PubMed:24643061, PubMed:25775587, PubMed:22343712). Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes (PubMed:24643061, PubMed:25775587). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:25775587). Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina (PubMed:24643061, PubMed:25775587). Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (PubMed:18583962). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (PubMed:14667410).
Cellular Location Isoform 1: Nucleus
Research Areas
Citations (0)

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Background

Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1.

References

Ando K.,et al.J. Mol. Endocrinol. 31:419-425(2003).
Koehler K.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Bhati M.,et al.EMBO J. 27:2018-2029(2008).

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$ 295.00
$ 99.00
Cat# AP20999c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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