(Mouse) Sox15 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P43267 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 25311 Da |
Antigen Region | 152-165 aa |
Gene ID | 20670 |
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Other Names | Protein SOX-15, Sox15, Sox-15 |
Target/Specificity | This (Mouse) Sox15 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 152-165 amino acids from the C-terminal region of human (Mouse) Sox15. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | (Mouse) Sox15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Sox15 |
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Synonyms | Sox-15 |
Function | Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (PubMed:10821863, PubMed:15863505, PubMed:16759287, PubMed:17363903). Acts as a transcriptional activator and repressor (PubMed:10821863, PubMed:15863505, PubMed:16759287). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (PubMed:15863505). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (PubMed:17363903). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (PubMed:10821863). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (PubMed:16759287). Regulates transcription of HRC via binding to its proximal enhancer region (PubMed:15863505). Involved in skeletal muscle regeneration (PubMed:15367664, PubMed:17363903). Also plays a role in the development of myogenic precursor cells (PubMed:15367664). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:10821863, ECO:0000269|PubMed:15367664, ECO:0000269|PubMed:17363903} |
Tissue Location | Expressed in myoblasts (at protein level) (PubMed:15367664). Expressed in embryonic stem cells (at protein level) (PubMed:15367664, PubMed:15863505). Expressed in myogenic progenitor cells (at protein level) (PubMed:17363903). Expressed in the ovary (PubMed:15367664). Expressed in kidney, liver, skeletal muscle, and testes (PubMed:10821863, PubMed:15367664). Expressed in lung and skin (PubMed:15863505). Expressed in the brain, heart, diaphragm, and intestines (PubMed:10821863). Expressed in the conceptus tissues of the placenta (PubMed:16759287). |
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Provided below are standard protocols that you may find useful for product applications.
References
Miyashita A.,et al.Gene 237:53-60(1999).
Beranger F.,et al.J. Biol. Chem. 275:16103-16109(2000).
Liu Y.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Stock D.W.,et al.Genomics 37:234-237(1996).
van de Wetering M.,et al.Nucleic Acids Res. 21:1669-1669(1993).
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