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PPAP2A Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PPAP2A Antibody (C-term) AP21024c
    Western blot analysis of lysate from Jurkat cell line, using PPAP2A Antibody (C-term)(Cat. #AP21024c). AP21024c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
    detail
  • WB - PPAP2A Antibody (C-term) AP21024c
    Western blot analysis of lysate from human kidney tissue lysate, using PPAP2A Antibody (C-term)(Cat. #AP21024c). AP21024c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
    detail
  • WB - PPAP2A Antibody (C-term) AP21024c
    Western blot analysis of lysate from human pancreas tissue lysate, using PPAP2A Antibody (C-term)(Cat. #AP21024c). AP21024c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O14494
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 32156 Da
Additional Information
Gene ID 8611
Other Names Lipid phosphate phosphohydrolase 1, PAP2-alpha, Phosphatidate phosphohydrolase type 2a, Phosphatidic acid phosphatase 2a, PAP-2a, PAP2a, PPAP2A, LPP1
Target/Specificity This PPAP2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 270-304 amino acids from the C-terminal region of human PPAP2A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPPAP2A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLPP1 (HGNC:9228)
Synonyms LPP1, PPAP2A
Function Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590). May also have an intracellular activity to regulate phospholipid- mediated signaling pathways (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein Apical cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:Q61469}; Multi-pass membrane protein
Tissue Location Widely expressed with highest expression found in prostate (PubMed:9305923). Found to be down-regulated in colon adenocarcinomas (PubMed:9570154). [Isoform 2]: Predominant in heart and pancreas.
Research Areas
Citations (0)
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Background

Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.

References

Kai M.,et al.J. Biol. Chem. 272:24572-24578(1997).
Leung D.W.,et al.DNA Cell Biol. 17:377-385(1998).
Ulrix W.E.J.,et al.J. Biol. Chem. 273:4660-4665(1998).
Roberts R.,et al.J. Biol. Chem. 273:22059-22067(1998).
Schmutz J.,et al.Nature 431:268-274(2004).

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$ 365.00
$ 140.00
Cat# AP21024c
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