|Application ||WB, FC, E|
|Other Accession||P24786, Q5IFJ9|
|Calculated MW||94428 Da|
|Other Names||NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NTRK3, TRKC|
|Target/Specificity||This NTRK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 393-426 amino acids from the Central region of human NTRK3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NTRK3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
McGregor L.M.,et al.Genomics 22:267-272(1994).
Shelton D.L.,et al.J. Neurosci. 15:477-491(1995).
Ichaso N.,et al.Oncogene 17:1871-1875(1998).
Ultsch M.H.,et al.J. Mol. Biol. 290:149-159(1999).
Greenman C.,et al.Nature 446:153-158(2007).
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