|Application ||WB, E|
|Calculated MW||52992 Da|
|Other Names||Lipase member I, LIPI, 311-, Cancer/testis antigen 17, CT17, LPD lipase, Membrane-associated phosphatidic acid-selective phospholipase A1-beta, mPA-PLA1 beta, LIPI, LPDL|
|Target/Specificity||This LIPI antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 224-258 amino acids from the Central region of human LIPI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LIPI Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).|
|Cellular Location||Isoform 1: Membrane. Secreted. Note=May associate with lipid draft|
|Tissue Location||Expressed in testis. Expressed exclusively at the connecting piece of the sperm.|
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Provided below are standard protocols that you may find useful for product applications.
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Hiramatsu T.,et al.J. Biol. Chem. 278:49438-49447(2003).
Wen X.-Y.,et al.Hum. Mol. Genet. 12:1131-1143(2003).
Hattori M.,et al.Nature 405:311-319(2000).
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