|Application ||WB, E|
|Calculated MW||130813 Da|
|Other Names||G-protein coupled receptor 126, gpr126|
|Target/Specificity||This DANRE gpr126 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1135-1169 amino acids from the C-terminal region of DANRE gpr126.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||(DANRE) gpr126 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:25118328). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:19745155). Plays also a role in inner ear development (PubMed:24067352).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in Schwann cells of the posterior lateral line nerve and in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Orphan receptor. Required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. Required for normal expression of the transcription factors oct6 and krox20 that are required for Schwann cells to inititate myelination.
Monk K.R.,et al.Science 325:1402-1405(2009).
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