|Application ||WB, E|
|Calculated MW||130813 Da|
|Other Names||G-protein coupled receptor 126, gpr126|
|Target/Specificity||This DANRE gpr126 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1135-1169 amino acids from the C-terminal region of DANRE gpr126.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||(DANRE) gpr126 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:25118328). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:19745155). Plays also a role in inner ear development (PubMed:24067352).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in Schwann cells of the posterior lateral line nerve and in brain.|
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Orphan receptor. Required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. Required for normal expression of the transcription factors oct6 and krox20 that are required for Schwann cells to inititate myelination.
Monk K.R.,et al.Science 325:1402-1405(2009).
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