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(DANRE) gpr126 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - (DANRE) gpr126 Antibody (C-term) AP21136a
    Western blot analysis of lysate from zebra fish brain tissue lysate, using (DANRE) gpr126 Antibody (C-term)(Cat. #AP21136a). AP21136a was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession C6KFA3
Reactivity Zebrafish
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 130813 Da
Additional Information
Gene ID 561970
Other Names G-protein coupled receptor 126, gpr126
Target/Specificity This DANRE gpr126 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1135-1169 amino acids from the C-terminal region of DANRE gpr126.
Dilution WB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(DANRE) gpr126 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name adgrg6
Synonyms gpr126
Function G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:25118328). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:19745155). Plays also a role in inner ear development (PubMed:24067352).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in Schwann cells of the posterior lateral line nerve and in brain.
Research Areas
Citations (0)

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Background

Orphan receptor. Required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. Required for normal expression of the transcription factors oct6 and krox20 that are required for Schwann cells to inititate myelination.

References

Monk K.R.,et al.Science 325:1402-1405(2009).

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$ 295.00
$ 99.00
Cat# AP21136a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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