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DOCK2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DOCK2 Antibody (C-term) AP21150a
    Anti-DOCK2 Antibody (C-term)at 1:2000 dilution + Jurkat whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 212 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - DOCK2 Antibody (C-term) AP21150a
    Western blot analysis of lysates from Jurkat, Raji cell line (from left to right), using DOCK2 Antibody (C-term)(Cat. #AP21150a). A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q92608
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 211948 Da
Additional Information
Gene ID 1794
Other Names Dedicator of cytokinesis protein 2, DOCK2, KIAA0209
Target/Specificity This DOCK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1812-1846 amino acids from the C-terminal region of human DOCK2.
Dilution WB~~1:1000-1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDOCK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOCK2
Synonyms KIAA0209
Function Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
Cellular Location Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin
Tissue Location Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon
Research Areas
Citations (0)

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Background

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.

References

Nagase T.,et al.DNA Res. 3:321-329(1996).
Nishihara H.,et al.Biochim. Biophys. Acta 1452:179-187(1999).
Nishihara H.,et al.Blood 100:3968-3974(2002).
Nishihara H.,et al.Biochem. Biophys. Res. Commun. 296:716-720(2002).
Cote J.-F.,et al.J. Cell Sci. 115:4901-4913(2002).

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$ 295.00
$ 99.00
Cat# AP21150a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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