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(Mouse) Sox2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P48432 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34454 Da |
| Gene ID | 20674 |
|---|---|
| Other Names | Transcription factor SOX-2, Sox2, Sox-2 |
| Target/Specificity | This Mouse Sox2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 34-68 amino acids from the N-terminal region of mouse Sox2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (Mouse) Sox2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Sox2 |
|---|---|
| Synonyms | Sox-2 |
| Function | Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739, PubMed:32703285). Binds to the proximal enhancer region of NANOG (PubMed:15863505). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:19349578, ECO:0000269|PubMed:32127020}. Cytoplasm Note=Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor. |
| Tissue Location | Expressed in the cochlea (at protein level) (PubMed:32127020). Expressed in the brain and retina (PubMed:7590241, PubMed:15863505). A very low level of expression is seen in the stomach and lung (PubMed:7590241, PubMed:15863505). Expressed in the kidney (PubMed:15863505). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
References
Yuan H.,et al.Genes Dev. 9:2635-2645(1995).
Yuan H.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Collignon J.,et al.Development 122:509-520(1996).
Tsuruzoe S.,et al.Biochem. Biophys. Res. Commun. 351:920-926(2006).
Takahashi K.,et al.Cell 126:663-676(2006).
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