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UBE2C Antibody (N-term G25)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - UBE2C Antibody (N-term G25) AP2119d
    Western blot analysis of UBE2C (arrow) using rabbit polyclonal UBE2C Antibody (N-term G25) (Cat. #AP2119d). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the UBE2C gene (Lane 2) (Origene Technologies).(8ug/ml)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00762
Other Accession Q9D1C1, Q4R9D1, Q32PA5
Reactivity Human
Predicted Bovine, Monkey, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 19652 Da
Antigen Region 10-39 aa
Additional Information
Gene ID 11065
Other Names Ubiquitin-conjugating enzyme E2 C, UbcH10, Ubiquitin carrier protein C, Ubiquitin-protein ligase C, UBE2C, UBCH10
Target/Specificity This UBE2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human UBE2C.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUBE2C Antibody (N-term G25) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2C
Synonyms UBCH10
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Research Areas
Citations (0)

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2C is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression.


Okamoto, Y., et al., Cancer Res. 63(14):4167-4173 (2003).
Lin, Y., et al., J. Biol. Chem. 277(24):21913-21921 (2002).
Townsley, F.M., et al., Proc. Natl. Acad. Sci. U.S.A. 94(6):2362-2367 (1997).

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$ 295.00
$ 99.00
Cat# AP2119d
(40 western blots)
Availability: In Stock
Bulk Size
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