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>   home   >   Products   >   Primary Antibodies   >   Mouse Neurog2 Antibody (C-term)   

Mouse Neurog2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Neurog2 Antibody (C-term) AP21257b
    Anti-Neurog2 Antibody (C-term)at 1:2000 dilution + Hela whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P70447
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Additional Information
Other Names Neurogenin-2, NGN-2, Helix-loop-helix protein mATH-4A, mATH4A, Protein atonal homolog 4, Neurog2, Ath4a, Atoh4, Ngn2
Target/Specificity This Mouse Neurog2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 247-282 amino acids from the C-terminal region of Mouse Neurog2.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Neurog2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Neurog2
Synonyms Ath4a, Atoh4, Ngn2
Function Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981} EMBL; U76207; AAC53028.1; -; Genomic_DNA EMBL; Y07621; CAA68900.1; -; mRNA EMBL; AF303001; AAG40769.1; -; Genomic_DNA CCDS; CCDS17825.1; - RefSeq; NP_033848.1; NM_009718.2 UniGene; Mm.42017; - ProteinModelPortal; P70447; - SMR; P70447; - BioGrid; 198240; 4 STRING; 10090.ENSMUSP00000029587; - iPTMnet; P70447; - PhosphoSitePlus; P70447; - PaxDb; P70447; - PRIDE; P70447; - GeneID; 11924; - KEGG; mmu:11924; - CTD; 63973; - MGI; MGI:109619; Neurog2 eggNOG; ENOG410IQ4B; Eukaryota eggNOG; ENOG410XZ4C; LUCA HOGENOM; HOG000063655; - HOVERGEN; HBG101129; - InParanoid; P70447; - KO; K09082; - PRO; PR:P70447; - Proteomes; UP000000589; Unplaced CleanEx; MM_NEUROG2; - GO; GO:0005634; C:nucleus; IDA:MGI GO; GO:0070888; F:E-box binding; IDA:UniProtKB GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI GO; GO:0007411; P:axon guidance; IMP:MGI GO; GO:0045165; P:cell fate commitment; IGI:MGI GO; GO:0048469; P:cell maturation; IMP:MGI GO; GO:0021954; P:central nervous system neuron development; IMP:MGI GO; GO:0030900; P:forebrain development; IMP:MGI GO; GO:0022008; P:neurogenesis; IDA:MGI GO; GO:0030182; P:neuron differentiation; IMP:MGI GO; GO:0001764; P:neuron migration; IMP:MGI GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; IDA:UniProtKB GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:MGI GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW CDD; cd00083; HLH; 1 Gene3D; 4.10.280.10; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR032655; Ngn2 PANTHER; PTHR19290:SF105; PTHR19290:SF105; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 1: Evidence at protein level; Activator; Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 263 Neurogenin-2 /FTId=PRO_0000127401 DOMAIN 112 164 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} CONFLICT 60 60 E -> G (in Ref. 2; CAA68900) SEQUENCE 263 AA; 28216 MW; 817EF8246BD8CABE CRC64; MFVKSETLEL KEEEEVLMLL GSASPASATL TPMSSSADEE EDEELRRPGS ARGQRGAEAE QGVQGSPASG AGGCRPGRLL GLMHECKRRP SRSRAVSRGA KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCAGAGGL QGALFTEAVL LSPGAALGAS GDSPSPPSSW SCTNSPASSS NSTSPYSCTL SPASPGSDVD YWQPPPPEKH RYAPHLPLAR DCI
Citations (0)

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Background

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

References

Sommer L.,et al.Mol. Cell. Neurosci. 8:221-241(1996).
Gradwohl G.,et al.Dev. Biol. 180:227-241(1996).
Simmons A.D.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Lin C.H.,et al.Dev. Biol. 265:234-245(2004).

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$ 295.00
$ 99.00
Cat# AP21257b
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(40 western blots)
Availability: In Stock
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