|Application ||WB, E|
|Calculated MW||35695 Da|
|Other Names||C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Stem cell growth factor, p47, CLEC11A, CLECSF3, LSLCL, SCGF|
|Target/Specificity||This CLEC11A antibody is generated from a rabbit immunized with a recombinant protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC11A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLECSF3, LSLCL, SCGF|
|Function||Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999). Important for repair and maintenance of adult bone (By similarity).|
|Cellular Location||Cytoplasm. Secreted|
|Tissue Location||Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.|
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Provided below are standard protocols that you may find useful for product applications.
Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.
Bannwarth S.,et al.J. Biol. Chem. 273:1911-1916(1998).
Mio H.,et al.Biochem. Biophys. Res. Commun. 249:124-130(1998).
Bannwarth S.,et al.Genomics 57:316-317(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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