|Application ||WB, E|
|Calculated MW||35695 Da|
|Other Names||C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Stem cell growth factor, p47, CLEC11A, CLECSF3, LSLCL, SCGF|
|Target/Specificity||This CLEC11A antibody is generated from a rabbit immunized with a recombinant protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC11A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLECSF3, LSLCL, SCGF|
|Function||Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.|
|Cellular Location||Cytoplasm. Secreted|
|Tissue Location||Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.|
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Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.
Bannwarth S.,et al.J. Biol. Chem. 273:1911-1916(1998).
Mio H.,et al.Biochem. Biophys. Res. Commun. 249:124-130(1998).
Bannwarth S.,et al.Genomics 57:316-317(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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