|Application ||WB, E|
|Calculated MW||118563 Da|
|Other Names||Probable E3 ubiquitin-protein ligase HERC4, 632-, HECT domain and RCC1-like domain-containing protein 4, HERC4, KIAA1593|
|Target/Specificity||This HERC4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 445-479 amino acids from the Central region of human HERC4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HERC4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.|
|Cellular Location||Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution|
|Tissue Location||Expressed in brain and testis and detected in heart and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity).
Hochrainer K.,et al.Genomics 85:153-164(2005).
Nagase T.,et al.DNA Res. 7:273-281(2000).
Deloukas P.,et al.Nature 429:375-381(2004).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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