INPP5A Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q14642 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47820 Da |
Gene ID | 3632 |
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Other Names | Type I inositol 1, 5-trisphosphate 5-phosphatase, 5PTase, INPP5A |
Target/Specificity | This INPP5A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 306-340 amino acids from the C-terminal region of human INPP5A. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | INPP5A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INPP5A (HGNC:6076) |
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Function | Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8769125, PubMed:8626616). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity). |
Cellular Location | Cell membrane; Lipid-anchor {ECO:0000269|PubMed:8626616, ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TNC9} |
Tissue Location | Predominantly expressed in heart, brain, and skeletal muscle (PubMed:8006039). In brain; high level in Purkinje cells (PubMed:8013665). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
References
de Smedt F.,et al.FEBS Lett. 347:69-72(1994).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Laxminarayan K.M.,et al.J. Biol. Chem. 269:17305-17310(1994).
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