|Application ||WB, E|
|Calculated MW||46251 Da|
|Other Names||Substance-P receptor, SPR, NK-1 receptor, NK-1R, Tachykinin receptor 1, TACR1, NK1R, TAC1R|
|Target/Specificity||This TACR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 363-397 amino acids from the C-terminal region of human TACR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TACR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Takeda Y.,et al.Biochem. Biophys. Res. Commun. 179:1232-1240(1991).
Hopkins B.,et al.Biochem. Biophys. Res. Commun. 180:1110-1117(1991).
Gerard N.P.,et al.Biochemistry 30:10640-10646(1991).
Takahashi K.,et al.Eur. J. Biochem. 204:1025-1033(1992).
Fong T.M.,et al.Mol. Pharmacol. 41:24-30(1992).
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