|Application ||WB, E|
|Calculated MW||58875 Da|
|Other Names||25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 24-OHase, Vitamin D(3) 24-hydroxylase, Cytochrome P450 24A1, Cytochrome P450-CC24, CYP24A1, CYP24|
|Target/Specificity||This CYP24A1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 34-64 amino acids from the N-terminal region of human CYP24A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP24A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has a role in maintaining calcium homeostasis. Catalyzes the adrenodoxin-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.|
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Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
Chen K.-S.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:4543-4547(1993).
Ren S.,et al.J. Biol. Chem. 280:20604-20611(2005).
Deloukas P.,et al.Nature 414:865-871(2001).
Chen K.-S.,et al.Biochim. Biophys. Acta 1263:1-9(1995).
Labuda M.,et al.J. Bone Miner. Res. 8:1397-1406(1993).
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