|Application ||WB, E|
|Calculated MW||43262 Da|
|Other Names||Caspase-4, CASP-4, ICE(rel)-II, Protease ICH-2, Protease TX, Caspase-4 subunit 1, Caspase-4 subunit 2, CASP4, ICH2|
|Target/Specificity||This CASP4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 163-197 amino acids from the Central region of human CASP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CASP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1.|
|Cellular Location||Endoplasmic reticulum membrane. Mitochondrion|
|Tissue Location||Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1.
Faucheu C.,et al.EMBO J. 14:1914-1922(1995).
Munday N.A.,et al.J. Biol. Chem. 270:15870-15876(1995).
Kamens J.,et al.J. Biol. Chem. 270:15250-15256(1995).
Fernandes-Alnemri T.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
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