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(Mouse) Uhrf2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - (Mouse) Uhrf2 Antibody (Center) AP21392c
    Anti-Uhrf2 Antibody (Center)at 1:1000 dilution + Jurkat whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 90 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q7TMI3
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 90106 Da
Additional Information
Gene ID 109113
Other Names E3 ubiquitin-protein ligase UHRF2, 632-, NIRF, Np95-like ring finger protein, Nuclear protein 97, Nuclear zinc finger protein Np97, Ubiquitin-like PHD and RING finger domain-containing protein 2, Ubiquitin-like-containing PHD and RING finger domains protein 2, Uhrf2, Nirf
Target/Specificity This Mouse Uhrf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 472-505 amino acids from the Central region of Mouse Uhrf2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(Mouse) Uhrf2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Uhrf2
Synonyms Nirf
Function E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00358, ECO:0000269|PubMed:21598301}. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3
Research Areas
Citations (0)

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Background

E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells.

References

Davenport J.W.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Mori T.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Pichler G.,et al.J. Cell. Biochem. 112:2585-2593(2011).

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$ 99.00
Cat# AP21392c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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