|Application ||WB, E|
|Calculated MW||147613 Da|
|Other Names||Receptor tyrosine-protein kinase erbB-3, Glial growth factor receptor, Proto-oncogene-like protein c-ErbB-3, Erbb3|
|Target/Specificity||This Mouse Erbb3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1076-1110 amino acids from the region of Mouse Erbb3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Erbb3 Antibody (P1076) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||In the muscle, expression localizes to the synaptic sites of muscle fibers|
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Provided below are standard protocols that you may find useful for product applications.
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
Yamauchi J.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Moscoso L.M.,et al.Dev. Biol. 172:158-169(1995).
Kwon H.S.,et al.J. Biol. Chem. 288:26357-26371(2013).
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