|Application ||WB, E|
|Calculated MW||232298 Da|
|Other Names||Plexin-B1, Semaphorin receptor SEP, PLXNB1, KIAA0407, PLXN5, SEP|
|Target/Specificity||This PLXNB1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1715-1749 amino acids from the C-terminal region of human PLXNB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLXNB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0407, PLXN5, SEP|
|Function||Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.|
|Tissue Location||Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Tamagnone L.,et al.Cell 99:71-80(1999).
Tamagnone L.,et al.Cell 104:321-321(2001).
Maestrini E.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:674-678(1996).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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