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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   SEMA4D Antibody (C-term)   

SEMA4D Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SEMA4D Antibody (C-term) AP21408b
    All lanes : Anti-SEMA4D Antibody (C-term) at 1:2000 dilution Lane 1: Jurkat whole cell lysates Lane 2: HL-60 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 96 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q92854
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 96150 Da
Additional Information
Gene ID 10507
Other Names Semaphorin-4D, A8, BB18, GR3, CD100, SEMA4D, C9orf164, CD100, SEMAJ
Target/Specificity This SEMA4D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 793-832 amino acids from the C-terminal region of human SEMA4D.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSEMA4D Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEMA4D
Synonyms C9orf164, CD100, SEMAJ
Function Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
Research Areas
Citations (0)

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Background

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.

References

Hall K.T.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:11780-11785(1996).
Humphray S.J.,et al.Nature 429:369-374(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Tamagnone L.,et al.Cell 99:71-80(1999).
Basile J.R.,et al.Mol. Cell. Biol. 25:6889-6898(2005).

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$ 295.00
$ 99.00
Cat# AP21408b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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