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WASL Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - WASL Antibody (N-term) AP21413a
    All lanes : Anti-WASL Antibody (N-term) at 1:2000 dilution Lane 1: C2C12 whole cell lysates Lane 2: PC-12 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 55 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O00401
Reactivity Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 54827 Da
Additional Information
Gene ID 8976
Other Names Neural Wiskott-Aldrich syndrome protein, N-WASP, WASL
Target/Specificity This WASL antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 165-198 amino acids from the N-terminal region of human WASL.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWASL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WASL
Function Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q91YD9}. Cytoplasm {ECO:0000250|UniProtKB:Q91YD9}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O08816}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm {ECO:0000250|UniProtKB:Q91YD9}
Research Areas
Citations (0)

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Background

Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.

References

Fukuoka M.,et al.Gene 196:43-48(1997).
Lennerz V.,et al.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
Suzuki T.,et al.EMBO J. 17:2767-2776(1998).
Egile C.,et al.J. Cell Biol. 146:1319-1332(1999).

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$ 295.00
$ 99.00
Cat# AP21413a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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