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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   LMX1A Antibody (C-term)   

LMX1A Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LMX1A Antibody (C-term) AP21429b
    Anti-LMX1A Antibody (C-term)at 1:2000 dilution + human liver lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 43 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - LMX1A Antibody (C-term) AP21429b
    Anti-LMX1A Antibody (C-term)at 1:2000 dilution + mouse small intestine lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 43 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8TE12
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Additional Information
Other Names LIM homeobox transcription factor 1-alpha, LIM/homeobox protein 11, LMX-11, LIM/homeobox protein LMX1A, LMX1A
Target/Specificity This LMX1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 303-337 amino acids from the C-terminal region of human LMX1A.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLMX1A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LMX1A
Function Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Tissue Location Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4AB is expressed in testis. EMBL; AY078398; AAL82892.1; -; Genomic_DNA EMBL; AY078391; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078392; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078393; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078394; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078395; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078396; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078397; AAL82892.1; JOINED; Genomic_DNA EMBL; AY078398; AAL82893.1; -; Genomic_DNA EMBL; AY078396; AAL82893.1; JOINED; Genomic_DNA EMBL; AY078397; AAL82893.1; JOINED; Genomic_DNA EMBL; AK127724; BAG54558.1; -; mRNA EMBL; AL160058; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL390730; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471067; EAW90744.1; -; Genomic_DNA EMBL; BC119743; AAI19744.1; -; mRNA EMBL; BC119744; AAI19745.1; -; mRNA CCDS; CCDS1247.1; -. [Q8TE12-1] RefSeq; NP_001167540.1; NM_001174069.1. [Q8TE12-1] RefSeq; NP_796372.1; NM_177398.3. [Q8TE12-1] UniGene; Hs.667312; - ProteinModelPortal; Q8TE12; - SMR; Q8TE12; - BioGrid; 110194; 5 IntAct; Q8TE12; 1 STRING; 9606.ENSP00000294816; - iPTMnet; Q8TE12; - PhosphoSitePlus; Q8TE12; - BioMuta; LMX1A; - DMDM; 27923801; - PaxDb; Q8TE12; - PeptideAtlas; Q8TE12; - PRIDE; Q8TE12; - ProteomicsDB; 74389; - ProteomicsDB; 74390; -. [Q8TE12-2] DNASU; 4009; - Ensembl; ENST00000294816; ENSP00000294816; ENSG00000162761. [Q8TE12-1] Ensembl; ENST00000342310; ENSP00000340226; ENSG00000162761. [Q8TE12-1] Ensembl; ENST00000367893; ENSP00000356868; ENSG00000162761. [Q8TE12-1] GeneID; 4009; - KEGG; hsa:4009; - UCSC; uc001gcz.3; human. [Q8TE12-1] CTD; 4009; - DisGeNET; 4009; - EuPathDB; HostDB:ENSG00000162761.14; - GeneCards; LMX1A; - HGNC; HGNC:6653; LMX1A HPA; HPA028051; - HPA; HPA030088; - MIM; 600298; gene neXtProt; NX_Q8TE12; - OpenTargets; ENSG00000162761; - PharmGKB; PA30416; - eggNOG; KOG0490; Eukaryota eggNOG; ENOG410YIJ3; LUCA GeneTree; ENSGT00760000118921; - HOGENOM; HOG000231629; - HOVERGEN; HBG052335; - InParanoid; Q8TE12; - KO; K09371; - OMA; NDSLWHE; - OrthoDB; EOG091G09Z3; - PhylomeDB; Q8TE12; - TreeFam; TF315442; - SIGNOR; Q8TE12; - ChiTaRS; LMX1A; human GeneWiki; LMX1A; - GenomeRNAi; 4009; - PRO; PR:Q8TE12; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000162761; - CleanEx; HS_LMX1A; - Genevisible; Q8TE12; HS GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISS:ParkinsonsUK-UCL GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl GO; GO:0007411; P:axon guidance; IEA:Ensembl GO; GO:0021549; P:cerebellum development; IEA:Ensembl GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl GO; GO:0071542; P:dopaminergic neuron differentiation; TAS:ParkinsonsUK-UCL GO; GO:0007626; P:locomotory behavior; IEA:Ensembl GO; GO:0007613; P:memory; IEA:Ensembl GO; GO:1904948; P:midbrain dopaminergic neuron differentiation; ISS:ParkinsonsUK-UCL GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl GO; GO:0042048; P:olfactory behavior; IEA:Ensembl GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:ParkinsonsUK-UCL GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl GO; GO:0050808; P:synapse organization; IEA:Ensembl CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR017970; Homeobox_CS InterPro; IPR001356; Homeobox_dom InterPro; IPR001781; Znf_LIM Pfam; PF00046; Homeobox; 1 Pfam; PF00412; LIM; 2 SMART; SM00389; HOX; 1 SMART; SM00132; LIM; 2 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS00027; HOMEOBOX_1; 1 PROSITE; PS50071; HOMEOBOX_2; 1 PROSITE; PS00478; LIM_DOMAIN_1; 2 PROSITE; PS50023; LIM_DOMAIN_2; 2 1: Evidence at protein level; Activator; Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc CHAIN 1 382 LIM homeobox transcription factor 1- alpha /FTId=PRO_0000075825 DOMAIN 33 92 LIM zinc-binding 1. {ECO:0000255|PROSITE- ProRule:PRU00125} DOMAIN 92 154 LIM zinc-binding 2. {ECO:0000255|PROSITE- ProRule:PRU00125} DNA_BIND 195 254 Homeobox. {ECO:0000255|PROSITE- ProRule:PRU00108} COMPBIAS 240 274 Gln-rich COMPBIAS 257 265 Poly-Gln VAR_SEQ 1 249 Missing (in isoform LMX1A-4AB) /FTId=VSP_003112 SEQUENCE 382 AA; 42747 MW; 55424762757FF5FD CRC64; MLDGLKMEEN FQSAIDTSAS FSSLLGRAVS PKSVCEGCQR VILDRFLLRL NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYDYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGTAEEGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL SSAQTNGGGS AGMEGIMNPY TALPTPQQLL AIEQSVYSSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS
Research Areas
Citations (0)

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Background

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).

References

Thameem F.,et al.Gene 290:217-225(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 295.00
$ 99.00
Cat# AP21429b
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(40 western blots)
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