|Application ||WB, E|
|Calculated MW||36043 Da|
|Other Names||Melanocortin receptor 3, MC3-R, MC3R|
|Target/Specificity||This MC3R antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 301-335 amino acids from the C-terminal region of human MC3R.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MC3R Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Brain, placental, and gut tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
Gantz I.,et al.J. Biol. Chem. 268:8246-8250(1993).
Kopatz S.A.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Tarnow P.,et al.Obes. Facts 5:45-51(2012).
Lee Y.-S.,et al.J. Clin. Endocrinol. Metab. 87:1423-1426(2002).
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