|Application ||WB, E|
|Calculated MW||44702 Da|
|Other Names||Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A, BMP2, BMP2A|
|Target/Specificity||This BMP2 antibody is generated from a rabbit immunized with a recombinant protein of human BMP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BMP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).|
|Tissue Location||Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
Induces cartilage and bone formation.
Wozney J.M.,et al.Science 242:1528-1534(1988).
Shore E.M.,et al.Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Yeung B.,et al.Anal. Chem. 69:2510-2516(1997).
Yanagita M.,et al.Biochem. Biophys. Res. Commun. 316:490-500(2004).
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