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BMP2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BMP2 Antibody AP21447a
    All lanes : Anti-BMP2 Antibody at 1:2000 dilution Lane 1: rat kidney lysates Lane 2: THP-1 whole cell lysates Lane 3: Hela whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 45 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P12643
Reactivity Human, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 44702 Da
Additional Information
Gene ID 650
Other Names Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A, BMP2, BMP2A
Target/Specificity This BMP2 antibody is generated from a rabbit immunized with a recombinant protein of human BMP2.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBMP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMP2
Synonyms BMP2A
Function Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Cellular Location Secreted.
Tissue Location Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine
Research Areas
Citations (0)

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Background

Induces cartilage and bone formation.

References

Wozney J.M.,et al.Science 242:1528-1534(1988).
Shore E.M.,et al.Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Yeung B.,et al.Anal. Chem. 69:2510-2516(1997).
Yanagita M.,et al.Biochem. Biophys. Res. Commun. 316:490-500(2004).

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$ 295.00
$ 99.00
Cat# AP21447a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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