|Application ||WB, E|
|Calculated MW||70415 Da|
|Other Names||Rab11 family-interacting protein 5, Rab11-FIP5, Gamma-SNAP-associated factor 1, Gaf-1, Phosphoprotein pp75, Rab11-interacting protein Rip11, RAB11FIP5, GAF1, KIAA0857, RIP11|
|Target/Specificity||This RAB11FIP5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 341-375 amino acids from the Central region of human RAB11FIP5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB11FIP5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GAF1, KIAA0857, RIP11|
|Function||Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.|
|Cellular Location||Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein Mitochondrion membrane; Peripheral membrane protein|
|Tissue Location||Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Prekeris R.,et al.Mol. Cell 6:1437-1448(2000).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Wang D.,et al.J. Clin. Invest. 104:1265-1275(1999).
Chen D.,et al.J. Biol. Chem. 276:13127-13135(2001).
Wallace D.M.,et al.Biochem. Biophys. Res. Commun. 299:770-779(2002).
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