- CITATIONS: 1
|Application ||WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||56158 Da|
|Other Names||Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial, 3-oxoacid CoA-transferase 1, Somatic-type succinyl-CoA:3-oxoacid CoA-transferase, SCOT-s, OXCT1, OXCT, SCOT|
|Target/Specificity||This OXCT1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 272-306 amino acids from the Central region of human OXCT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OXCT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts|
Provided below are standard protocols that you may find useful for product applications.
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
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Schmutz J.,et al.Nature 431:268-274(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Reymond M.A.,et al.Submitted (FEB-1997) to UniProtKB.
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