|Application ||WB, E|
|Calculated MW||47993 Da|
|Other Names||DNA (cytosine-5)-methyltransferase 3-like, Dnmt3l|
|Target/Specificity||This Mouse Dnmt3l antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 383-417 amino acids from the C-terminal region of Mouse Dnmt3l.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Dnmt3l Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases.|
|Tissue Location||Expressed in testis, thymus, ovary, and heart.|
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Provided below are standard protocols that you may find useful for product applications.
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases.
Aapola U.,et al.Cytogenet. Cell Genet. 92:122-126(2001).
Shaoping X.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Bourc'his D.,et al.Science 294:2536-2539(2001).
Gowher H.,et al.J. Biol. Chem. 280:13341-13348(2005).
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