|Application ||WB, E|
|Calculated MW||133799 Da|
|Other Names||Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1|
|Target/Specificity||This JAG1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1190-1224 amino acids from the C-terminal region of human JAG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JAG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells|
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Provided below are standard protocols that you may find useful for product applications.
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Oda T.,et al.Genomics 43:376-379(1997).
Li L.,et al.Nat. Genet. 16:243-251(1997).
Li L.,et al.Immunity 8:43-55(1998).
Bash J.,et al.EMBO J. 18:2803-2811(1999).
Gray G.E.,et al.Am. J. Pathol. 154:785-794(1999).
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