|Application ||WB, E|
|Calculated MW||133799 Da|
|Other Names||Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1|
|Target/Specificity||This JAG1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1190-1224 amino acids from the C-terminal region of human JAG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JAG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells|
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Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Oda T.,et al.Genomics 43:376-379(1997).
Li L.,et al.Nat. Genet. 16:243-251(1997).
Li L.,et al.Immunity 8:43-55(1998).
Bash J.,et al.EMBO J. 18:2803-2811(1999).
Gray G.E.,et al.Am. J. Pathol. 154:785-794(1999).
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