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WNT7A Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - WNT7A Antibody AP21552a
    Anti-WNT7A Antibody at 1:2000 dilution + human uterus lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 39 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O00755
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 39005 Da
Additional Information
Gene ID 7476
Other Names Protein Wnt-7a, WNT7A
Target/Specificity This WNT7A antibody is generated from a rabbit immunized with a recombinant protein of human WNT7A.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWNT7A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WNT7A
Function Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity).
Cellular Location Secreted, extracellular space, extracellular matrix. Secreted
Tissue Location Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain
Research Areas
Citations (0)
citation

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Background

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).

References

Bui T.D.,et al.Gene 189:25-29(1997).
Ikegawa S.,et al.Cytogenet. Cell Genet. 74:149-152(1996).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Huguet E.L.,et al.Cancer Res. 54:2615-2621(1994).
Woods C.G.,et al.Am. J. Hum. Genet. 79:402-408(2006).

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$ 182.50
$ 70.00
Cat# AP21552a
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