|Application ||WB, E|
|Calculated MW||55528 Da|
|Other Names||Phosphatidylserine synthase 1, PSS-1, PtdSer synthase 1, Serine-exchange enzyme I, PTDSS1, KIAA0024, PSSA|
|Target/Specificity||This PTDSS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 427-461 amino acids from the C-terminal region of human PTDSS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||PTDSS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Highly enriched in the mitochondria-associated membrane (MAM).|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.
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Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Kuge O.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:4199-4203(1998).
Olsen J.V.,et al.Cell 127:635-648(2006).
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