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TNK1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13470 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72468 Da |
| Gene ID | 8711 |
|---|---|
| Other Names | Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1, TNK1 {ECO:0000312|EMBL:AAC994121} |
| Target/Specificity | This TNK1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 554-588 amino acids from the C-terminal region of human TNK1. |
| Dilution | WB~~1:1000- 1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TNK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNK1 {ECO:0000312|EMBL:AAC99412.1} |
|---|---|
| Function | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein |
| Tissue Location | Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
References
Hoehn G.T.,et al.Oncogene 12:903-913(1996).
Hoehn G.T.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Felschow D.M.,et al.Biochem. Biophys. Res. Commun. 273:294-301(2000).
Olsen J.V.,et al.Cell 127:635-648(2006).
Hoare S.,et al.Cancer Res. 68:8723-8732(2008).
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