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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TNK1 Antibody (C-term)   

TNK1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TNK1 Antibody (C-term) AP21591b
    All lanes : Anti-TNK1 Antibody (C-term) at 1:1000-1:2000 dilution Lane 1: human testis lysates Lane 2: Hela whole cell lysates Lane 3: Jurkat whole cell lysates Lane 4: PC-3 whole cell lysates Lane 5: T47D whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 72 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13470
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 72468 Da
Additional Information
Gene ID 8711
Other Names Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1, TNK1 {ECO:0000312|EMBL:AAC994121}
Target/Specificity This TNK1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 554-588 amino acids from the C-terminal region of human TNK1.
Dilution WB~~1:1000- 1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNK1 {ECO:0000312|EMBL:AAC99412.1}
Function Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Tissue Location Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
Research Areas
Citations (0)

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Background

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

References

Hoehn G.T.,et al.Oncogene 12:903-913(1996).
Hoehn G.T.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Felschow D.M.,et al.Biochem. Biophys. Res. Commun. 273:294-301(2000).
Olsen J.V.,et al.Cell 127:635-648(2006).
Hoare S.,et al.Cancer Res. 68:8723-8732(2008).

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$ 99.00
Cat# AP21591b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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