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SPCS1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - SPCS1 Antibody (Center) AP21622c
    All lanes : Anti-SPCS1 Antibody (Center) at 1:2000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: T47D whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 12 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y6A9
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 18298 Da
Additional Information
Gene ID 28972
Other Names Signal peptidase complex subunit 1, 34--, Microsomal signal peptidase 12 kDa subunit, SPase 12 kDa subunit, SPCS1, SPC12
Target/Specificity This SPCS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 66-100 amino acids from the Central region of human SPCS1.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPCS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPCS1
Synonyms SPC12
Function Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Dispensable for SPC enzymatic activity (By similarity).
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P83362}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P83362}
Research Areas
Citations (0)
citation

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Background

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

References

Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalies K.-U.,et al.J. Biol. Chem. 271:3925-3929(1996).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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$ 365.00
$ 140.00
Cat# AP21622c
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