|Application ||WB, E|
|Calculated MW||72548 Da|
|Other Names||Delta-like protein C, DeltaC, delC, dlc|
|Target/Specificity||This DANRE dlc antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 557-591 amino acids from DANRE dlc.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||(DANRE) dlc Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Strongly expressed in the early retina, where it precedes other delta proteins. Also expressed in cranial ganglia, in sensory epithelia including ear and lateral line and in scattered epidermal cells. In the mesoderm, expression is visible by 50% epiboly; it is expressed subsequently in the tail bud, in stripes in the presomitic mesoderm and in the posterior half of each somite. Also expressed in notochord, blood vessels and pronephros. In contrast to other delta proteins, it is not expressed in the majority of nascent primary neurons. In somites, it marks the posterior part of each formed somite, while deltaD (dld) marks the anterior part.|
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Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.
Smithers L.E.,et al.Mech. Dev. 90:119-123(2000).
Jiang Y.-J.,et al.Nature 408:475-479(2000).
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