|Application ||WB, E|
|Calculated MW||146407 Da|
|Other Names||Bile salt export pump, ATP-binding cassette sub-family B member 11, ABCB11, BSEP|
|Target/Specificity||This ABCB11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1063-1097 amino acids from the C-terminal region of human ABCB11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABCB11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Strautnieks S.S.,et al.Nat. Genet. 20:233-238(1998).
Mol O.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mochizuki K.,et al.Am. J. Physiol. 292:G818-G828(2007).
Jansen P.L.M.,et al.Gastroenterology 117:1370-1379(1999).
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