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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   TFDP2 Antibody (Center)   

TFDP2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TFDP2 Antibody (Center) AP21655c
    All lanes : Anti-TFDP2 Antibody (Center) at 1:2000 dilution Lane 1: A431 whole cell lysate Lane 2: human heart lysate Lane 3: human skeletal muscle whole cell lysate Lane 4: Hela whole cell lysate Lane 5: HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 49 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q14188
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 49236 Da
Additional Information
Gene ID 7029
Other Names Transcription factor Dp-2, E2F dimerization partner 2, TFDP2, DP2
Target/Specificity This TFDP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 175-208 amino acids from the Central region of human TFDP2.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTFDP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFDP2
Synonyms DP2
Function Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Cellular Location Nucleus.
Tissue Location High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines
Research Areas
Citations (0)

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Background

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis.

References

Wu C.-L.,et al.Mol. Cell. Biol. 15:2536-2546(1995).
Zhang Y.,et al.Oncogene 10:2085-2093(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Li W.B.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).

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$ 295.00
$ 99.00
Cat# AP21655c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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