|Application ||WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||117532 Da|
|Other Names||Inactive tyrosine-protein kinase 7, Protein chuzhoi, Protein-tyrosine kinase 7, Pseudo tyrosine kinase receptor 7, Tyrosine-protein kinase-like 7, Ptk7|
|Target/Specificity||This Mouse Ptk7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 702-737 amino acids from the C-terminal region of Mouse Ptk7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Ptk7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Cell junction. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells|
|Tissue Location||Expressed at high levels in lung and un- pregnant uterus among adult tissues, and in the tail, limbs, somites, gut and craniofacial regions among embryonic tissues|
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Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Jung J.-W.,et al.Gene 328:75-84(2004).
Carninci P.,et al.Science 309:1559-1563(2005).
Daigo Y.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Lu X.,et al.Nature 430:93-98(2004).
Gundry R.L.,et al.Mol. Cell. Proteomics 8:2555-2569(2009).
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