|Application ||WB, E|
|Calculated MW||150891 Da|
|Other Names||Serine/threonine-protein kinase LMTK3, Apoptosis-associated tyrosine kinase 3, Lemur tyrosine kinase 3, Lmtk3, Aatyk3|
|Target/Specificity||This Mouse Lmtk3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 871-905 amino acids from the Central region of Mouse Lmtk3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Lmtk3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D- aspartate receptors (NMDAR) in neurons (PubMed:24760852).|
|Cellular Location||Membrane; Single-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections|
|Tissue Location||Expressed in brain. Predominantly expressed in cerebral cortex, thalamus, the cerebellum and hippocampal formation (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Tomomura M.,et al.Neuroscience 148:510-521(2007).
Trinidad J.C.,et al.Mol. Cell. Proteomics 5:914-922(2006).
Munton R.P.,et al.Mol. Cell. Proteomics 6:283-293(2007).
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